Hypoglycemic A result of Musa Sapientum on Alloxan-Induced Diabetic Rats and the Resulting Effect of Ast Activity in Brain and Heart Essay

Hypoglycemic Effect of Methanolic Extract of Nspiracion Sapientum Sucker, in Alloxan-Induced Diabetic Rodents, and Its Comparable Effect on Aspartate Transaminase in Activity in Brain and Heart

Oseni Kehinde Ajibola

April 08

ABSTRACT

Musa sapientum is an herb used in Nigeria folklore to get the treatment of diabetes mellitus. The sucker part of the plant utilized for this try things out and the blood sugar level, weight and AST activity was determined in Musa sapientum treated diabetic rats and normal mice. Oral supervision of Letras sapientum sucker showed significant decrease in blood glucose level in alloxan caused diabetic rodents at 5mg and 10mg\kg body weight concentrations (78. 33±12. 70 and 63. 0±3. 57 respectively) compared with neglected diabetic rodents (252. 20±26. 19). The weight losses of the mice were also restored after treatment with this kind of plant. In the brain, there is a high significant difference between the used herb i actually. e. Musa sapientum for both concentrations 5mg and 10mg (24. 33±3. fifty five and 19. 81±3. 28 respectively) in comparison to the control group (38. 87±4. 58). In comparison with the glibenclamide group, there were a significant big difference (p< zero. 05) between Musa sapientum group (24. 33±3. fifty-five for 5mg and 19. 81±3. 28 for 10mg) and the glibenclamide treated rodents (49. 99±4. 58). Though the activity was higher at 10mg attention than the 5mg group. In the heart, it had been observed that at (p< 0. 05), there was small significant difference between control (28. 87±2. 82), the 5mg (25. 55±3. 95) and 10mg\kg body weight group (24. 33±3. 55). When compared with glibenclamide (38. 86±4. 58) in (p< 0. 05) there was clearly high factor between Nspiracion sapientum group [5mg (25. 55±3. 95), 10mg (24. 33±3. 55)] and this. Conclusively, based on the above principles, Musa sapientum sucker contains a positive impact on AST activity in the organs stated over compared to glibenclamide.

LIST OF FURNITURE

TABLE you: Showing differential changes in the fasting blood sugar in several rat groups for a month. TABLE two: Showing the game of AST (U/L) in brain with the various verweis groups. TABLE 3: Showing the activity of AST (U/L) in heart of the various rat teams.

CHAPTER A SINGLE

1 . 0 INTRODUCTION

Herbal products in kind of leaves, barks, stems, plants of plant life have generally been regarded as medicinal. However some have been applied as supply of food, but what is generally attributed to herbs can be their phytochemical properties. Locally, herbs have been completely used for treatment of various illnesses without any medical basis. They may be just applied due to natural instinct and inheritance we. e. a specific remedy for diseases been transferred from one era to another. The herbs happen to be collected by various times of the day but commonly in the evening when supposedly the effect is definitely high. The herbs are processed in numerous forms; many are cut in small parts and soaked with water or liquor in a bottle of wine and sometimes will be soaked with soft drinks (7up) with the purpose extracting it is important parts for treatment. Some natural herbs (leaves and flowers) will be mashed in to powdery kind after they will be sun-dried then used with meals in kind of fluid (pap, ogi in Yoruba). Many are superstitious positioned around the stomach, entrances, under their beds etc expecting that they will serve some curing purposes. But with scientist (biochemist, pharmacologist, microbiologist etc . ) working thoroughly on natural herbs, various discoveries have been built showing the wide range of beneficial values and effects of these types of herbs. Diabetes on the other hand identifies a condition where the pituitary gland increases urinary output (diabetes insipidus) or maybe a disorder where the pancreas creates defects in insulin creation or action, thus causing hyperglycemia (diabetes mellitus). [Stedman's Medical Dictionary, (2006)] As a result of increasing frequency of diabetes in the world and mostly in the developed countries, a lot of researches have been done to look for the effect of herbs in diabetes and...



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